Nordic Life Science 1
BUSINESS PRESENTATION MILTENYIBIOTEC.SE The MACSQ
uant Tyto Sorter makes use of very low–pressure filtered air for exceptionally gentle cell treatment, resulting in never-before-seen viability and functionality in a sterile, GMP-compliant, fully closed setup. always of concern in traditional cell sorting, necessitating laborious cleaning protocols. The MACSQuant® Tyto® Sorter eliminates all of these concerns. Samples are kept in sterile, disposable, fully closed cartridges, which means no risk of contamination of any kind, and no chance of aerosol and droplet formation. American politician Anna Eshoo once described innovation as the calling card of the future. With that in mind, a good case could be made for listing the Nordic region as the address on that card. The cutting-edge biomedical research that takes place in its plethora of prominent institutions and renowned biotech firms attests to that. Although not a native Scandinavian firm, Miltenyi Biotec sits comfortably nestled in arguably the heart of all that activity, Lund. FROM ITS FOUNDATION, Miltenyi Biotec has focused on thinking differently, whether through pushing forward new frontiers or simply seeing minor adjustments to existing processes. Often, this has led the multidisciplinary team around the founder to create products for previously unthought of applications. Based on the then revolutionary MACS® Technology, the firm’s 14,000+ products were, and continue to be, created by its 475 dedicated R&D employees, supported by a sales force and customer service department well-known for their scientific literacy and helpful counsel. Such an output of innovation is possible through continual interaction and collaboration with the scientific community, reflecting Miltenyi Biotec’s fundamental belief that new ideas are created by the sharing of experiences between some of the world’s most brilliant and creative minds. More recently, this deep-rooted understanding of, and appreciation for, the real-life challenges faced in the research environment led to one of our most revolutionary products yet; the MACSQuant® Tyto® Sorter. Traditional cell-sorting techniques are droplet-based, which means precious cell samples are subjected to high pressures, decompression, and electrical charges. Not only can all of these factors potentially impact on the viability and functionality of the cell population of interest, the droplet method can lead to the formation of biohazardous aerosols, endangering the researcher and requiring both additional time and capital to offset. Finally, sample-to-sample carry-over and external contamination are Since all cell sorting takes place exclusively within the disposable cartridge, no cleaning is required either. Instead, a microchip at the bottom of the cartridge enables high-speed, fluorescence-based sorting via the world’s fastest mechanical sort valve into either the positive or the negative collection chambers. Cells to be sorted are driven through this system by very low-pressure filtered air without the need for decompression or the application of a charge. This exceptionally gentle cell treatment results in never-before-seen viability and functionality of isolated cell populations, which in turn means more conclusive and reproducible research findings. The entire process is plug-and-play, requiring minimal operator training, and nine times less hands-on time with the instrument in total compared with conventional droplet-based cell sorters. But such an innovative new technology doesn’t just improve existing processes with added convenience; it opens up entirely new applications. For example, because cell sorting takes place entirely within the closed system of the MACSQuant® Tyto® Cartridge, cells remain sterile. And since there is no sheath fluid, using the system with MACS® GMP Tyto Consumables means the cells only ever come into contact with MACS® GMP products. This makes Miltenyi Biotec the first company ever to offer sterile, GMP-compliant multiparametric cell sorting in a fully closed setup, opening up entirely new possibilities in translational and clinical research settings. It is our belief that this sort of breakthrough concept is the result of an authentic adherence to the scientific mindset; to always question how things are done, and how they can be done better; through collaboration, and through the free and frank exchange of challenges, successes, and ideas. NLS MILTENYI BIOTEC NORDEN AB SCHEELEVÄGEN 17, 223 70 LUND, SWEDEN, +46 46 280 72 80, MACS@MILTENYIBIOTEC.SE