Nordic Life Science 1
TOP STORIES BUSINESS COV ID-19 Colorized scanning
electron micrograph of an apoptotic cell (green) heavily infected with SARS-COV-2 virus particles (purple), isolated from a patient sample. just a few mutations away from evading existing vaccines, and we know that even vaccinated people can both pass on the infection and become ill themselves,” says Carl-Johan Dalsgaard, CEO, Vicore Pharma. “This C21/ CoV patent gives Vicore patent protection in the US market until December 2040.” A major clinical impact of COV ID-19 C21 on respiratory function in COVID-19 was documented in a recent phase 2 trial showing that C21 reduced the need for supplemental oxygen in hospitalized patients by 90%. An ongoing international phase 3 study (ATTRACT-3) involving around 600 COVID19 patients is expected to deliver top-line data in H1 2022. is now supplemented with further analyses showing that the vaccine candidate protects against disease and elicits neutralizing antibodies against both the wild strain and the delta variant of the virus. In addition, local protection against viral challenge in the nasal mucosa could be demonstrated. “There are few vaccines against COVID19 under development that are adapted for intranasal administration, but the interest in these has increased in recent months as it has been seen that even fully vaccinated people can carry and transmit infection. In the event that a financially stronger partner is interested in taking the project further, we are open to licensing our platform. Should new variants or diseases appear, we have shown that once antigens have been identified, Abera can in a short time create new, adapted vaccine candidates,” says Maria Alriksson, CEO, Abera Bioscience. Abera’s vaccine platform makes it possible to decorate bacterial Outer Membrane Vesicles (OMVs) with multiple antigens. In the study, OMVs were decorated with the antigenic SARS-CoV-2 Spike receptor-binding domain and tested in a golden hamster infection model. Carl-Johan Dalsgaard, CEO, Vicore Pharma 14 NORDICLIFESCIENCE.ORG PHOTO NIAID